Education
Ph.D. in Biostatistics, University of Southern California, Los Angeles, CA, 2008
M.S. in Biometry, University of Southern California, Los Angeles, CA, 2001
M.S. in Biochemistry, Peking University, Beijing, China, 1998
B.S. in Microbiology, Peking University, Beijing, China, 1995
Research Areas
- Designs and some critical issues of Phase I, II, and III clinical trials
- Dose-Toxicity Bayesian models in Cancer Phase I Clinical Trials
- A novel toxicity score system to measure the multiple toxicities per patient quantitatively and comprehensively in Phase I clinical trials
- Methods treating disease response as a continuous variable instead of using RECIST in Phase II clinical trials
Selected Publications
1. Chen Z, Krailo MD, Sun J, Azen SP. Range and trend of expected toxicity level (ETL) in standard A+B designs: A report from the children's oncology group. Contemporary Clinical Trials. 2009; 30(2):123-8.
2. Chen Z, Krailo MD, Sun J, Azen SP. An Extended Isotonic Phase I Design Treating Toxicity Response as a Quasi-Continuous Variable. The Society for Clinical Trials 30th Annual Meeting. 2009 May 3-6. Abstract No: A13.
3. Bomgaars LR, Bernstein M., Krailo M., Kadota R, Das S., Chen Z, Adamson PC, and Blaney SM. Phase II trial of irinotecan in children with refractory solid tumors: a Children's Oncology Group study. Journal of Clinical Oncology. 2007; 25(29):4622-7.
4. Bhatia S, Krailo MD, Chen Z, Burden L, Askin FB, Dickman PS, Grier HE, Link MP, Meyers PA, Perlman EJ, Rausen AR, Robison LL, Vietti TJ, Miser JS. Therapy-related myelodysplasia and acute myeloid leukemia after Ewing sarcoma and primitive neuroectodermal tumor of bone: A report from the Children's Oncology Group. Blood. 2007; 109(1):46-51.
5. Chen Z, Wu AH, Gauderman J, Bernstein L, Ma H, Pike MC, Ursin G. Does mammographic density reflect ethnic differences in breast cancer incidence rates? American Journal of Epidemiology 2004; 159:140-147.
6. Chen Z, Ren L, Shao Q, Shi D, Ru B. Expression of mammalian metallothionein-I gene in cyanobacteria to enhance heavy metal resistance. Marine Pollution Bulletin 1999; 39(1-12): 155-158.
7. Chen Z, Li XF, Shi DJ, et al. Studies on the purification, characterization and conformation in solution of metallothionein-like substance from Synechocystis 6803. Acta Botanica Sinica 1999; 41(2): 150-155.
Professional Memberships
- American Statistical Association
- The Society for Clinical Trials
- American Association of Cancer Research
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